Peer-reviewed veterinary case report
Young cat with worsening unsteady walk from rare brain and spinal
By Elisa Chludzinski et al.·Published in Frontiers in Veterinary Science·2021·Department of Pathology, University of Veterinary Medicine, Hannover, Germany, CH·View original on DOAJ →
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Original publication title: Case Report: Primary Diffuse Leptomeningeal Oligodendrogliomatosis in a Young Adult Cat
- Species:
- cat
Plain-English summary
A 2-year-old cat was brought to the vet because it was having trouble walking and seemed uncoordinated. Unfortunately, despite treatment, the cat passed away. A thorough examination revealed a widespread tumor affecting the membranes around the brain and spinal cord, which was made up of abnormal cells. This type of tumor, called primary diffuse leptomeningeal oligodendrogliomatosis, is very rare in young cats. The findings suggest that this condition should be considered when diagnosing similar cases in cats.
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Abstract
A 2-year-old cat was presented with progressive ataxia. Despite treatment the animal died. Pathomorphological examination revealed a widespread leptomeningeal mass at all levels of the central nervous system accentuated on the cervical spinal cord and the medulla oblongata without presence of a primary intraaxial tumor. The neoplasm was mainly composed of round, uninucleate cells with hyperchromatic nuclei, which were immunopositive for OLIG2, doublecortin, MAP2, synaptophysin, and vimentin, indicating components of both oligodendroglial and neuronal differentiation. Ki-67 immunohistochemistry indicated a high proliferation activity of the neoplasm. Few GFAP positive and Iba-1 positive cells were interpreted as reactive astrocytes and macrophages or microglia, respectively. The tumor was immunonegative for CD3, CD20, PAX5, MUM1, pan-cytokeratin, S100, NSE, p75NTR, NeuN and periaxin. These findings led to the diagnosis of primary diffuse leptomeningeal oligodendrogliomatosis. This is the first reported case of this entity in a young cat, which should be considered as a differential diagnosis for diffuse subarachnoidal round cell infiltrates.
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Search related cases →Original publication on DOAJ: https://doi.org/10.3389/fvets.2021.795126