Peer-reviewed veterinary case report
Young cat with worsening unsteady walk from rare brain and spinal
By Chludzinski, Elisa et al.·Published in Frontiers in veterinary science·2021·Department of Pathology, Germany·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Case Report: Primary Diffuse Leptomeningeal Oligodendrogliomatosis in a Young Adult Cat.
- Species:
- cat
Plain-English summary
A 2-year-old cat was brought to the vet because it was having trouble walking and showed signs of unsteadiness, known as ataxia. Unfortunately, despite treatment, the cat passed away. A thorough examination revealed a widespread tumor in the membranes surrounding the brain and spinal cord, which was made up of abnormal cells. This type of tumor, called primary diffuse leptomeningeal oligodendrogliomatosis, is rare and was found for the first time in a young cat.
People also search for: cat ataxia causes · young cat brain tumor symptoms · cat neurological disease treatment
Abstract
A 2-year-old cat was presented with progressive ataxia. Despite treatment the animal died. Pathomorphological examination revealed a widespread leptomeningeal mass at all levels of the central nervous system accentuated on the cervical spinal cord and the medulla oblongata without presence of a primary intraaxial tumor. The neoplasm was mainly composed of round, uninucleate cells with hyperchromatic nuclei, which were immunopositive for OLIG2, doublecortin, MAP2, synaptophysin, and vimentin, indicating components of both oligodendroglial and neuronal differentiation. Ki-67 immunohistochemistry indicated a high proliferation activity of the neoplasm. Few GFAP positive and Iba-1 positive cells were interpreted as reactive astrocytes and macrophages or microglia, respectively. The tumor was immunonegative for CD3, CD20, PAX5, MUM1, pan-cytokeratin, S100, NSE, p75, NeuN and periaxin. These findings led to the diagnosis of primary diffuse leptomeningeal oligodendrogliomatosis. This is the first reported case of this entity in a young cat, which should be considered as a differential diagnosis for diffuse subarachnoidal round cell infiltrates.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34977226/