Peer-reviewed veterinary case report
Severe high triglycerides in healthy Labrador on low-dose rapamycin
By Evans, Jeremy B et al.·Published in Frontiers in veterinary science·2023·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Case report: Severe asymptomatic hypertriglyceridemia associated with long-term low-dose rapamycin administration in a healthy middle-aged Labrador retriever.
- Species:
- dog
Plain-English summary
An 8-year-old male Labrador retriever developed very high triglyceride levels after being given a low dose of rapamycin, a medication sometimes used to extend lifespan. Despite this, the dog showed no symptoms and appeared healthy during the six months of treatment, although there was a noticeable increase in fat in his blood. After stopping the rapamycin, the dog's triglyceride levels returned to normal within just 15 days without any additional treatment.
People also search for: dog high triglycerides treatment · Labrador retriever health issues · rapamycin side effects in dogs
Abstract
Rapamycin is an mTOR inhibitor that has been shown to extend the lifespan of laboratory model organisms. In humans, rapamycin is used at higher doses as an immunosuppressive medication to prevent organ rejection. Numerous adverse effects are seen with rapamycin treatment in humans, with one of the most common being dysregulation of lipid metabolism. In humans, this often manifests as mild to moderate serum lipid elevations, with a small subset developing extreme triglyceride elevations. This case report describes an eight-year-old, castrated male, clinically healthy Labrador retriever who developed severe hypertriglyceridemia associated with low-dose rapamycin administration over a six-month period. During this time, the dog was asymptomatic and displayed no other clinical abnormalities, aside from a progressive lipemia. Within 15 days of discontinuing rapamycin treatment, and with no targeted lipemic intervention, the dog's lipemia and hypertriglyceridemia completely resolved.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38094495/