Peer-reviewed veterinary case report
Severe high blood fat in healthy middle-aged Labrador on low-dose
By Jeremy B. Evans et al.·Published in Frontiers in Veterinary Science·2023·Department of Small Animal Clinical Sciences, Texas A&M School of Veterinary Medicine & Biomedical Sciences, College Station, TX, United States, CH·View original on DOAJ →
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Original publication title: Case report: Severe asymptomatic hypertriglyceridemia associated with long-term low-dose rapamycin administration in a healthy middle-aged Labrador retriever
- Species:
- dog
Plain-English summary
An 8-year-old male Labrador retriever developed very high triglyceride levels after being given a low dose of rapamycin, a medication sometimes used to extend lifespan. Despite the severe hypertriglyceridemia, the dog showed no symptoms and appeared healthy during the six months of treatment. After stopping the rapamycin, the dog's triglyceride levels returned to normal within just 15 days without any additional treatment. This case highlights the importance of monitoring lipid levels in pets receiving certain medications.
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Abstract
Rapamycin is an mTOR inhibitor that has been shown to extend the lifespan of laboratory model organisms. In humans, rapamycin is used at higher doses as an immunosuppressive medication to prevent organ rejection. Numerous adverse effects are seen with rapamycin treatment in humans, with one of the most common being dysregulation of lipid metabolism. In humans, this often manifests as mild to moderate serum lipid elevations, with a small subset developing extreme triglyceride elevations. This case report describes an eight-year-old, castrated male, clinically healthy Labrador retriever who developed severe hypertriglyceridemia associated with low-dose rapamycin administration over a six-month period. During this time, the dog was asymptomatic and displayed no other clinical abnormalities, aside from a progressive lipemia. Within 15 days of discontinuing rapamycin treatment, and with no targeted lipemic intervention, the dog’s lipemia and hypertriglyceridemia completely resolved.
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Search related cases →Original publication on DOAJ: https://doi.org/10.3389/fvets.2023.1285498