Peer-reviewed veterinary case report
Cat Kidney Glomeruli and Tubules Evaluated by Design-Based Stereology.
- Journal:
- Anatomical record (Hoboken, N.J. : 2007)
- Year:
- 2019
- Authors:
- Sadeghinezhad, Javad & Nyengaard, Jens R
- Affiliation:
- Department of Basic Sciences
- Species:
- cat
Plain-English summary
This study looked at the structure of cat kidneys to better understand how their shape and size relate to kidney function. Researchers used a special technique called stereology to measure various parts of the kidneys in four cats. They found that the average kidney volume was about 11.4 cm, with specific measurements for the outer and inner parts of the kidney, as well as the number and size of tiny filtering units called glomeruli. The findings aim to help improve diagnosis and treatment of kidney diseases in cats by providing a clearer picture of their kidney structure. Overall, this research adds valuable information about cat kidneys that could be useful for veterinary care.
Abstract
Renal function is related to its structure and three-dimensional structural parameters correlate better with the kidney function than two-dimensional structural parameters. Stereology is the current gold-standard technique for the morphometrical evaluation of kidney structures. This study describes morphometric features of the kidney of the cat using design-based stereological techniques aimed to introduce the cat as a translational model in nephrology and provide basic findings for diagnosis and treatment of kidney diseases in this species. Left kidneys of four cats were included in the present study. The kidney volume, volume fraction of cortex and medulla, glomerular volume, glomerular mean volume, glomerular number, and proximal convoluted tubule (PCT) and distal convoluted tubule (DCT) length were estimated. The kidney volume was estimated to 11.4 ± 1.3 cm. The volume fraction of cortex and medulla was 65.6 ± 2% and 34.2 ± 2%, respectively. The total number of glomeruli was estimated to be 186 ± 11 × 10using the physical disector/fractionator method. The mean glomerular volume was estimated to be 1.54 ± 0.06 × 10μmand the glomerular volume was covering 2.13 ± 0.34% of the whole kidney. The total length of PCT and DCT was estimated to be 2.26 ± 0.48 km and 505 ± 43 m, respectively. Our data might contribute to the knowledge of kidneys in mammals and provide a comparison with available data on human and other mammals. Anat Rec, 302:1846-1854, 2019. © 2019 American Association for Anatomy.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31087775/