Peer-reviewed veterinary case report
Understanding feline genetics from nose to tail
By Lyons, Leslie A·Published in Trends in genetics : TIG·2021·Department of Veterinary Medicine & Surgery, United States·View original on PubMed →
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Original publication title: Cats - telomere to telomere and nose to tail.
- Species:
- cat
Plain-English summary
Recent research shows that scientists can use advanced genetic techniques to better understand the DNA of cats, which may help us learn more about human genetics as well. By creating complete genome maps for all cat species, researchers can study how cats have evolved and how their genes are organized. This work suggests that cats might also help us understand how certain genetic variations affect how genes are turned on and off. Overall, this research could lead to important insights in both feline and human health.
Abstract
Feline genomic medicine can decode human variants of uncertain significance (VUSs). Telomere-to-telomere genome assemblies are feasible for all felid species, supporting genetic evolution and speciation studies. Their highly conserved genomic organization compared to humans suggests cats may also decipher the intergenic variation affecting the 3D chromosome structures influencing gene regulation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34332790/