Peer-reviewed veterinary case report
Dogs with inflammatory bowel disease have fewer CD11c+ immune cells
By Kathrani, A et al.·Published in Journal of comparative pathology·2011·Department of Veterinary Clinical Sciences, United Kingdom·View original on PubMed →
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Original publication title: CD11c+ cells are significantly decreased in the duodenum, ileum and colon of dogs with inflammatory bowel disease.
- Species:
- dog
Plain-English summary
A group of dogs with inflammatory bowel disease (IBD) showed significantly fewer immune cells called CD11c(+) cells in their intestines compared to healthy dogs. These immune cells are important for gut health, and their reduction may be linked to the chronic inflammation seen in IBD. The study involved biopsies from affected dogs and healthy controls, revealing that the lower the number of these cells, the more severe the dog's symptoms were. Understanding this relationship could help veterinarians diagnose and monitor IBD in dogs more effectively.
People also search for: dog inflammatory bowel disease symptoms · IBD treatment for dogs · why is my dog having diarrhea · dog gut health immune cells
Abstract
CD11c serves as a marker for human and murine dendritic cells (DCs) and cells expressing this marker have been shown to have similar morphological and functional characteristics in the canine immune system. The aim of this study was to quantify CD11c(+) cells in the duodenum, ileum and colon of healthy dogs and dogs with inflammatory bowel disease (IBD). Endoscopic biopsies from the duodenum (n=12 cases), ileum (n=8 cases) and colon (n=12 cases) were obtained from dogs diagnosed with IBD. Intestinal tissue from 10 healthy beagle dogs was used as control. Immunofluorescence microscopy was carried out using an anti-canine CD11c monoclonal antibody. Labelled cells were recorded as cells per 120,000 μm(2). The canine chronic enteropathy clinical activity index (CCECAI) was calculated for all dogs with IBD. In addition, sections from all dogs with IBD were evaluated according to the guidelines of the World Small Animal Veterinary Association Gastrointestinal Standardization Group. The number of CD11c(+) cells in the duodenum, ileum and colon of dogs with IBD was significantly reduced compared with controls (P<0.01, P<0.01 and P<0.05, respectively). There was a significant negative correlation between the number of CD11c(+) cells in the colon of dogs with IBD and the CCECAI (P=0.044, r(2)=-0.558). Chronic inflammation in canine IBD appears to involve an imbalance in the intestinal DC population. Future studies will determine whether reduced expression of CD11c could be a useful marker for the diagnosis and monitoring of canine IBD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21592490/