Peer-reviewed veterinary case report
CD40-associated TRAF 6 signaling is required for disease induction in a retrovirus-induced murine immunodeficiency.
- Journal:
- Journal of virology
- Year:
- 2004
- Authors:
- Green, Kathy A et al.
- Affiliation:
- Department of Microbiology and Immunology · United States
- Species:
- rodent
Abstract
LP-BM5 retrovirus-infected C57BL/6 mice develop splenomegaly, lymphadenopathy, hypergammaglobulinemia, and immunodeficiency; thus, this disease has been named mouse AIDS. In this syndrome, CD154/CD40 interactions are required for but do not mediate disease by upregulation of CD80 or CD86. We report here that there is nonetheless a necessity for CD40 signaling competence, specifically an intact tumor necrosis factor receptor-associated factor 6 (TRAF 6) binding site.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15141004/