Peer-reviewed veterinary case report
CD8+ T cells reduce in vitro interferon-gamma production in Theiler's murine encephalomyelitis virus-induced demyelinating disease model.
- Journal:
- Multiple sclerosis (Houndmills, Basingstoke, England)
- Year:
- 2004
- Authors:
- Denton, Paul W et al.
- Affiliation:
- Department of Microbiology and Immunology · United States
- Species:
- rodent
Abstract
In the Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease model for multiple sclerosis, regulatory CD8+ T cells prevent demyelinating disease and reduce in vivo interferon (IFN)-gamma production by anti-TMEV CD4+ blast cells in BALB/c mice. We describe here that regulatory CD8+ T cells reduce in vitro IFN-gamma production by lymph node cells from both TMEV and fowl gamma globulin immunized mice without affecting interleukin (IL)-4, IL-10, tumour growth factor-beta or tumour necrosis factor-alpha production.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15327031/