Peer-reviewed veterinary case report
Ceftriaxone Treatment for Neuronal Deficits: A Histological and MEMRI Study in a Rat Model of Dementia with Lewy Bodies.
- Journal:
- Behavioural neurology
- Year:
- 2018
- Authors:
- Ho, Ying-Jui et al.
- Affiliation:
- Department of Psychology
- Species:
- rodent
Abstract
Dementia with Lewy bodies (DLB) is characterized by neuronal deficits and-synuclein inclusions in the brain. Ceftriaxone (CEF), a-lactam antibiotic, has been suggested as a therapeutic agent in several neurodegenerative disorders for its abilities to counteract glutamate-mediated toxicity and to block-synuclein polymerization. By using manganese-enhanced magnetic resonance imaging (MEMRI) and immunohistochemistry, we measured the effects of CEF on neuronal activity and-synuclein accumulation in the brain in a DLB rat model. The data showed that CEF corrected neuronal density and activity in the hippocampal CA1 area, suppressed hyperactivity in the subthalamic nucleus, and reduced-synuclein accumulation, indicating that CEF is a potential agent in the treatment of DLB.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30154934/