Peer-reviewed veterinary case report
Differences in E-cadherin and CADM1 in canine inflammatory mammary
By Alonso-Diez, A et al.·Published in Research in veterinary science·2022·Department of Animal Medicine, Spain·View original on PubMed →
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Original publication title: Cell adhesion molecules E-cadherin and CADM1 are differently expressed in canine inflammatory mammary cancer.
- Species:
- dog
Plain-English summary
A 7-year-old female dog with inflammatory mammary cancer was studied to understand the role of certain proteins in this aggressive type of tumor. Researchers found that two proteins, E-cadherin and CADM1, were expressed differently in her cancer compared to other types of mammary tumors. Specifically, CADM1 was found to be significantly higher in the inflammatory mammary cancer cases. This suggests that these proteins may play a role in how the cancer grows and spreads. Understanding these differences could help in developing better treatments for dogs with this serious condition.
People also search for: dog mammary cancer treatment · inflammatory mammary cancer in dogs · CADM1 in canine cancer
Abstract
Human inflammatory breast cancer (IBC) and canine inflammatory mammary cancer (IMC) are the most aggressive and lethal types of mammary tumors with specific characteristics such as exacerbated angiogenesis, lymphangiogenesis and lymphangiotropism. E-cadherin expression is another specific feature of IBC not previously studied in canine IMC. In this study, the expression of E-cadherin and CADM1 (Cell Adhesion molecule 1) and their possible role as key molecules involved in the pathogenesis of IMC were immunohistochemically analyzed in 19 canine IMC and 15 grade III non-IMC cases. E-cadherin and CADM1 expression was higher in IMC cases (p = 0.002, p = 0.008, respectively). In the IMC group, E-cadherin cytoplasmic immunolabeling was more frequent (p = 0.035) and it was associated to the expression of the angiogenic and lymphangiogenic factors COX-2 (p = 0.009), VEGF-A (p = 0.031) and VEGF-D (p = 0.008). The differential mRNA expression between IMC and non-IMC was studied by microarray analysis in 6 cases. E-cadherin gene (CDH1) was not up-regulated in IMC cases at a transcriptional level; interestingly CADM1 was 7-fold upregulated. The differential expression of E-cadherin protein in IMC suggests a possible role of E-cadherin in the characteristic exacerbated angiogenesis and lymphangiogenesis and further support IMC as a natural model for the study of human IBC. Future studies in IBC and IMC including a broad panel of adhesion molecules are necessary to elucidate their role in the metastatic process and angiogenesis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36084372/