Peer-reviewed veterinary case report
Immune responses in cats after feline herpesvirus vaccine
By Wu, Hongchao et al.·Published in Frontiers in veterinary science·2024·College of Veterinary Medicine, China·View original on PubMed →
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Original publication title: Cellular and humoral immune responses in cats vaccinated with feline herpesvirus 1 modified live virus vaccine.
- Species:
- cat
Plain-English summary
A group of cats vaccinated with a modified live virus vaccine for feline herpesvirus 1 (FHV-1) showed fewer signs of illness and higher levels of protective antibodies compared to unvaccinated cats. The vaccine not only boosted antibody levels but also enhanced the immune response, helping the cats fight off the virus more effectively. This means that vaccinating your cat against FHV-1 can significantly reduce their risk of developing respiratory issues associated with this virus. Overall, the study highlights the importance of vaccination in keeping cats healthy and protected from FHV-1.
People also search for: cat herpesvirus vaccine effectiveness · feline respiratory infection prevention · vaccinated cat symptoms after FHV-1 vaccine
Abstract
Feline herpesvirus 1 (FHV-1) is an important pathogen causing infectious rhinotracheitis in felids, mainly infecting the upper respiratory tract and conjunctiva. Multiple vaccines are available to prevent FHV-1 infection, and the antibody levels are always used to evaluate their effectiveness. However, the cellular immunity response following immunization in cats remains unclear. This study investigated the immune responses (humoral and cellular) in cats immunized with the FHV-1 modified live virus vaccine. The results indicated that vaccination significantly reduced clinical signs, and antibody levels, including virus-neutralizing (VN) antibodies and immunoglobulin G (IgG), in the vaccine group were higher than those in the control groups. Additionally, the vaccine significantly increased cytokine secretion, indicating Th1-type cellular immune responses in cats. Moreover, cellular immune-related indicators, such as CD8+ T cells, CD4+ T cells, and interferon-gamma levels, were inversely correlated with clinical signs post-challenge by FHV-1 in vaccinated cats, highlighting its crucial role in protecting cats against FHV-1 infection. In summary, this study demonstrated the importance of cellular immune responses in protecting cats from FHV-1 infection after vaccination.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39881722/