Peer-reviewed veterinary case report
Cellular senescence in pathologic retinal angiogenesis.
- Journal:
- Trends in endocrinology and metabolism: TEM
- Year:
- 2021
- Authors:
- Fu, Zhongjie & Smith, Lois E H
- Affiliation:
- Department of Ophthalmology · United States
Abstract
Pathologic angiogenesis causes blindness in many eye diseases. Crespo-Garcia, Tsuruda, and Dejda et al. employed bioinformatics to characterize cell senescence as a primary factor in the common pathogenesis of retinopathies. They validated their findings using human and mouse retina with proliferative retinopathy. Clearance of senescent cells suppressed neovessel growth.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/33863618/