Peer-reviewed veterinary case report
Diabetes insipidus after pituitary surgery in dogs with Cushing's
By Teshima, Takahiro et al.·Published in The Journal of veterinary medical science·2011·Department of Veterinary Science, Japan·View original on PubMed →
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Original publication title: Central diabetes insipidus after transsphenoidal surgery in dogs with Cushing's disease.
- Species:
- dog
Plain-English summary
A group of dogs with Cushing's disease underwent a type of surgery called transsphenoidal surgery (TSS) to remove their pituitary gland. After the surgery, many of these dogs developed central diabetes insipidus (CDI), which can cause excessive thirst and urination. The study found that the size of the pituitary gland before surgery could help predict whether the CDI would be temporary or permanent. Dogs with a larger pituitary gland were more likely to have permanent CDI. Treatment with desmopressin, a medication that helps manage CDI, was necessary for some of the dogs, indicating that their condition might not resolve on its own.
People also search for: dog Cushing's disease surgery · central diabetes insipidus in dogs · desmopressin for dogs · dog excessive thirst after surgery
Abstract
Transsphenoidal surgery (TSS) is an effective treatment for canine Cushing's disease, as well as human Cushing's disease. In humans, only the pituitary adenoma tissue is resected by TSS. However, in dogs, the whole pituitary including normal tissue is resected. Hence, central diabetes insipidus (CDI) may complicate the postoperative course in almost all dogs with Cushing's disease treated by TSS. However, it is difficult to assess the duration of the postoperative CDI, and whether it may be transient or permanent. In this study, postoperative CDI in 21 dogs with Cushing's disease and its predicted prognosis by preoperative parameters was investigated. In this study, CDI after TSS was classified as either transient or permanent based on the requirement for desmopressin. Preoperative circulating serum cortisol concentrations and pre- and post-operative plasma AVP concentrations were not significantly different between the transient CDI dogs and permanent CDI dogs. The duration of postoperative CDI was not correlated to the signal intensity ratio (posterior lobe of the pituitary/cerebral cortex), which is obtained from preoperative magnetic resonance imaging (MRI). However, the pituitary height/brain area (P/B) ratio of the permanent CDI dogs was significantly greater than that of the transient CDI dogs. In addition, there was a significant difference between the enlarged-pituitary (P/B ratio > 0.31) transient CDI dogs and the permanent CDI dogs. These results suggest that the incidence of postoperative permanent CDI is strongly influenced by the pituitary size.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20736519/