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Peer-reviewed veterinary case report

Cerebellar cortical abiotrophy causing cerebellar dysfunction

By Jokinen, T S et al.·Published in The Journal of small animal practice·2007·Department of Clinical Veterinary Sciences·View original on PubMed

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Original publication title: Cerebellar cortical abiotrophy in Lagotto Romagnolo dogs.

Species:
dog
Brain & nervesDogs

Plain-English summary

Two unrelated Lagotto Romagnolo dogs showed signs of cerebellar dysfunction, which can affect coordination and balance. One dog had unusual changes in the cerebellar cortex, while the other had more widespread degeneration. Both dogs displayed similar symptoms, but the severity varied between them. Unfortunately, the report does not mention any specific treatments or outcomes for these cases.

People also search for: Lagotto Romagnolo cerebellar dysfunction · dog balance problems · inherited dog brain disease

Abstract

This case report documents two pathological variations of potentially inherited, cerebellar cortical abiotrophy in two unrelated Lagotto Romagnolo breed dogs. The first dog had an atypical lesion in the cerebellar cortex with depletion of cerebellar granular cell layer and sparing of the Purkinje cell layer. The second case had degenerative changes in both Purkinje and granular cell layers. The clinical picture was similar in both cases presented, although the severity of the signs of cerebellar dysfunction varied.

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Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17490444/