Peer-reviewed veterinary case report
Doberman Pinscher dog diagnosed with brain fluid disease signs
By Vilander, Allison C et al.·Published in Veterinary clinical pathology·2019·Department of Microbiology, United States·View original on PubMed →
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Original publication title: Cerebral spinal fluid cytology from a Doberman Pinscher.
- Species:
- dog
Plain-English summary
A 3-year-old male Doberman Pinscher was brought to the vet because he was showing neurological signs and had severe liver disease. After testing his cerebral spinal fluid, the vet suspected a rare genetic condition called mucopolysaccharidosis type I (MPS I), which was confirmed through urine and blood tests. Interestingly, this dog had a different genetic background than other breeds typically affected by this condition. This case is notable as it's the first report of MPS I in Doberman Pinschers.
People also search for: Doberman Pinscher neurological signs · liver disease in dogs · mucopolysaccharidosis type I in dogs
Abstract
A 3-year-old intact male Doberman Pinscher dog was presented with neurologic signs and severe hepatic disease, and lysosomal storage disease was suspected based on inclusions in large mononuclear cells of the cerebral spinal fluid analysis. The dog was diagnosed with mucopolysaccharidosis type I (MPS I) via a urinary metabolic screen and serum enzyme activity tests but was homozygous wild-type when tested for the knowngene variants that cause MPS I in other dog breeds. This is the first report of MPS I in Doberman Pinscher dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31062371/