Peer-reviewed veterinary case report
Cerebral vascular hamartoma with thrombosis in a dog.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2011
- Authors:
- Sakurai, Masashi et al.
- Affiliation:
- Department of Veterinary Pathology · Japan
- Species:
- dog
Plain-English summary
A 7-year-old male Shih Tzu was found to have a growth in the right side of his brain, specifically in areas called the frontal lobe, striatum, and thalamus. This growth, known as a cerebral vascular hamartoma, is made up of abnormal blood vessels that are thin-walled and sometimes contain small blood clots. The structure of these vessels is not typical, lacking some of the usual muscle and elastic tissue. The diagnosis suggests that this condition could be similar to certain types of blood vessel malformations seen in people. The treatment details and outcome were not provided in the abstract.
Abstract
A cerebral vascular hamartoma was identified in the frontal lobe, striatum and thalamus of the right side of the brain of a male, 7-year-old Shih Tzu. Histologically, the lesion consisted of thin-walled vessels, which showed various sizes and occasionally contained fibrin thrombi. These vascular walls were composed of a single layer of fibromuscular tissue lined by flat endothelium with various amount of collagen, but devoid of large coat of smooth muscles and elastic tissue. Immunohistochemically, the lining endothelial cells were positive for von Willebrand Factor antibody. Neuropil between the vessels was stained with Klüver-Barrera stain, and positive for synaptophysin and GFAP antibodies. Based on these findings, the lesion was diagnosed as vascular hamartoma, which might resemble venous malformation in humans.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21646748/