Peer-reviewed veterinary case report
Inflammatory markers in dog spinal fluid after spinal cord injury
By Taylor, Amanda R et al.·Published in Journal of neurotrauma·2014·1 Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Cerebrospinal fluid inflammatory cytokines and chemokines in naturally occurring canine spinal cord injury.
- Species:
- dog
Plain-English summary
A group of dogs with spinal cord injuries caused by intervertebral disk herniation (IVDH) were studied to understand the inflammation in their cerebrospinal fluid. The researchers found that levels of a specific protein called IL-8 were higher in these injured dogs compared to healthy ones, and higher IL-8 levels were linked to longer injury duration. Additionally, other proteins like MCP-1 were associated with poorer recovery outcomes after 42 days. This research helps shed light on the inflammatory processes that occur in dogs with spinal cord injuries and could guide future treatments.
People also search for: dog spinal cord injury treatment · intervertebral disk herniation in dogs · dog recovery from spinal injury
Abstract
Canine intervertebral disk herniation (IVDH) is a common, naturally occurring form of spinal cord injury (SCI) that is increasingly being used in pre-clinical evaluation of therapies. Although IVDH bears critical similarities to human SCI with respect to lesion morphology, imaging features, and post-SCI treatment, limited data are available concerning secondary injury mechanisms. Here, we characterized cerebrospinal fluid (CSF) cytokines, and chemokines in dogs with acute, surgically treated, thoracolumbar IVDH (n=39) and healthy control dogs (n=21) to investigate early inflammatory events after SCI. A bioplex system was used to measure interleukin (IL)-2, -6, -7, -8, -10, -15, and -18, granulocyte macrophage colony-stimulating factor (GM-CSF), interferon gamma (IFN-γ), keratinocyte chemoattractant (KC)-like protein, IFN-γ-inducible protein-10, monocyte chemotactic protein 1 (MCP-1), and tumor necrosis factor alpha. Cytokine and chemokine concentrations in the CSF of healthy and SCI dogs were compared and, in SCI dogs, were correlated to the duration of SCI, behavioral measures of injury severity at the time of sampling, and neurological outcome 42 days post-SCI as determined by a validated ordinal score. IL-8 concentration was significantly higher in SCI cases than healthy controls (p=0.0013) and was negatively correlated with the duration of SCI (p=0.042). CSF MCP-1 and KC-like protein were positively correlated with CSF microprotein concentration in dogs with SCI (p<0.0001 and p=0.004). CSF MCP-1 concentration was negatively associated with 42-day postinjury outcome (p<0.0001). Taken together, these data indicate that cytokines and chemokines present after SCI in humans and rodent models are associated with SCI pathogenesis in canine IVDH.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24786364/