Peer-reviewed veterinary case report
Chain reactions: early-life stress alters the metabolic profile of plasma polyunsaturated fatty acids in adulthood.
- Journal:
- Behavioural brain research
- Year:
- 2009
- Authors:
- Clarke, Gerard et al.
- Affiliation:
- Department of Psychiatry
- Species:
- rodent
Abstract
The rat maternal separation paradigm can be used to examine the biological consequences of early-life stress. Immunomodulatory polyunsaturated fatty acids (PUFAs) have recently attracted attention in the study of stress-related disorders. We established the plasma PUFA profile of maternally separated rodents compared to controls. Our results identify a proinflammatory PUFA profile as a persistent consequence of early-life stress and suggest new avenues of investigation in stress-related disorders.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19616034/