Peer-reviewed veterinary case report
Challenges and opportunities for modeling aging and cancer.
- Journal:
- Cancer cell
- Year:
- 2023
- Authors:
- Anczuków, Olga et al.
- Affiliation:
- The Jackson Laboratory for Genomic Medicine · United States
- Species:
- rodent
Abstract
Age is among the main risk factors for cancer, and any cancer study in adults is faced with an aging tissue and organism. Yet, pre-clinical studies are carried out using young mice and are not able to address the impact of aging and associated comorbidities on disease biology and treatment outcomes. Here, we discuss the limitations of current mouse cancer models and suggest strategies for developing novel models to address these major gaps in knowledge and experimental approaches.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/37001528/