Peer-reviewed veterinary case report
Gene changes in tumor necrosis factor and interleukin 6 in dogs
By Song, Ruhui et al.·Published in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire·2016·Department of Veterinary Internal Medicine, South Korea·View original on PubMed →
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Original publication title: Changes in gene expression of tumor necrosis factor alpha and interleukin 6 in a canine model of caerulein-induced pancreatitis.
- Species:
- dog
Plain-English summary
This study looked at how certain genes related to inflammation behave in dogs with acute pancreatitis, which is a serious condition where the pancreas becomes inflamed. The researchers caused pancreatitis in dogs using a substance called caerulein and found that two specific inflammatory markers, tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6), increased significantly within three hours. They also noticed that levels of digestive enzymes in the blood rose, and there were signs of severe swelling in the pancreas and surrounding areas. The findings suggest that studying pancreatitis in dogs can help us understand and treat similar severe infections in both pets and people. Overall, the study highlights the importance of pancreatitis as a model for understanding serious inflammatory conditions.
Abstract
Acute pancreatitis is an inflammatory process that frequently involves peripancreatic tissues and remote organ systems. It has high morbidity and mortality rates in both human and veterinary patients. The severity of pancreatitis is generally determined by events that occur after acinar cell injury in the pancreas, resulting in elevated levels of various proinflammatory mediators, such as interleukin (IL) 1β and 6, as well as tumor necrosis factor alpha (TNF-α). When these mediators are excessively released into the systemic circulation, severe pancreatitis occurs with systemic complications. This pathophysiological process is similar to that of sepsis; thus, there are many striking clinical similarities between patients with septic shock and those with severe acute pancreatitis. We induced acute pancreatitis using caerulein in dogs and measured the change in the gene expression of proinflammatory cytokines. The levels of TNF-α and IL-6 mRNA peaked at 3 h, at twice the baseline levels, and the serum concentrations of amylase and lipase also increased. Histopathological examination revealed severe hyperemia of the pancreas and hyperemia in the duodenal villi and the hepatic sinusoid. Thus, pancreatitis can be considered an appropriate model to better understand the development of naturally occurring sepsis and to assist in the effective treatment and management of septic patients.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27408338/