Peer-reviewed veterinary case report
Interferon-gamma and neopterin levels in female dogs
By Dąbrowski, Roman et al.·Published in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire·2020·Department and Clinic of Animal Reproduction, Spain·View original on PubMed →
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Original publication title: Changes in interferon-gamma and neopterin in female dogs undergoing ovariohysterectomy as elective spay or as treatment of pyometra.
- Species:
- dog
Plain-English summary
A female dog with pyometra, a serious infection of the uterus, was brought in for surgery to remove her reproductive organs. Before the surgery, her blood tests showed higher levels of certain immune markers compared to healthy dogs undergoing routine spaying. After the surgery, the levels of one of these markers decreased significantly, indicating a positive response to the treatment. Overall, the surgery helped improve her condition, and she showed signs of recovery after the procedure.
People also search for: dog pyometra symptoms · spaying a dog recovery · female dog surgery blood tests
Abstract
The objective of this study was to determine serum concentrations of interferon-gamma (INF-γ) and neopterin (Np) in dogs with pyometra admitted for surgical treatment and to compare these concentrations to healthy dogs admitted for elective spay. The effects of the surgical procedure were also evaluated by measuring these markers in both groups of dogs before and after ovariohysterectomy. Our study indicates that pre-surgery concentrations of INF-γ (57.4 ± 26.0 pg/mL) and Np (5.6 ± 0.8 nmol/L) in healthy dogs were significantly lower compared to dogs with pyometra (124.3 ± 87.6 pg/mL for INF-γ; 7.0 ± 1.5 nmol/L for Np) (< 0.05 in both cases). Furthermore, Np was lower in dogs with pyometra 3 days after surgery compared to healthy controls (< 0.001). During the post-operative period, INF-γ showed no statistically significant changes in any of the groups, while Np showed lower serum concentration on day 3 than on day 0 in the pyometra group (< 0.001). No statistically significant correlation was detected between serum concentrations of INF-γ and Np. These results indicate that pyometra causes alterations in serum concentrations of INF-γ and Np in female dogs compared to physiological levels before surgery and during the postoperative period.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32801459/