Changes in lectin-binding patterns in the kidneys of canines with immune-complex mediated glomerulonephritis.

Abstract

We surveyed the kidneys of dogs with immune-complex mediated glomerulonephritis (ICGN) by lectin histochemistry using seven lectins-namely WGA, RCA-I, ConA, PNA, SBA, DBA, and UEA-I. Their binding patterns were compared with those from normal dogs. RCA-I signals became weak in the brush borders of the proximal tubules, whereas DBA signals became positive in Bowman's capsules. Also, varying intensity of the UEA-I signal was noted in the distal tubules, especially in the macula densa. The binding pattern profiles varied among the cases; this diversity in the lectin-binding patterns might be induced as a result of the diverse pathologies seen in canine ICGN.