Peer-reviewed veterinary case report
Platelet function changes in Dachshunds with early mitral valve
By Moesgaard, S G et al.·Published in Research in veterinary science·2009·Department of Basic Animal and Veterinary Sciences·View original on PubMed →
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Original publication title: Changes in platelet function in Dachshunds with early stages of myxomatous mitral valve disease.
- Species:
- dog
Plain-English summary
A group of 34 Dachshunds was examined for early signs of heart disease called myxomatous mitral valve disease, which can cause problems like heart murmurs. The study found that 12 of these dogs had longer closure times in a platelet function test, indicating potential issues with how their blood platelets work. This suggests that some Dachshunds with mild heart problems might have a form of platelet dysfunction. While the study didn't find significant differences in other blood markers, the results highlight the importance of monitoring these dogs for heart health and potential complications.
People also search for: Dachshund heart disease symptoms · myxomatous mitral valve disease treatment · dog platelet function test
Abstract
The aim of this study was to evaluate platelet function in Dachshunds during early stages of myxomatous mitral valve disease. Clinical examination and echocardiography were performed in 34 wirehaired standard sized Dachshunds. Platelet function was evaluated using the PFA-100 (reported as closure time). In addition, whole blood platelet aggregation response and hemostatic markers were evaluated. Significant longer PFA-100 closure time (CT) was found in 12 Dachshunds with mild mitral regurgitation (MR) compared to 22 Dachshunds with minimal MR. Only five Dachshunds responded to adenosine diphosphate in the whole blood aggregation analyses. There were no differences between the two dog groups in plasma fibrinogen, plasma von Willebrand factor (vWf) or vWf multimer distribution; however, there was a significant correlation between CT and plasma vWf concentration and CT and plasma fibrinogen concentration. The higher CT found in Dachshunds with mild MR suggests a form of platelet dysfunction in Dachshunds with MR.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18789461/