Peer-reviewed veterinary case report
Serum leptin changes before and after gallbladder surgery in dogs
By Lee, Sungin et al.·Published in BMC veterinary research·2019·Department of Veterinary Clinical Sciences College of Veterinary Medicine and Research Institute for Veterinary Science, South Korea·View original on PubMed →
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Original publication title: Changes in pre- and postoperative serum leptin concentrations in dogs with gallbladder mucocele and cholelithiasis.
- Species:
- dog
Plain-English summary
A group of 26 dogs, including those with gallbladder mucocele and cholelithiasis (gallstones), underwent surgery to remove their gallbladders. After the operation, the dogs were monitored for changes in a hormone called leptin, which can indicate health status. Dogs that recovered showed a significant drop in leptin levels over the first week, while those that did not survive did not show these changes. The study suggests that measuring leptin levels could help veterinarians assess the severity of gallbladder issues and predict recovery outcomes after surgery.
People also search for: dog gallbladder surgery recovery · leptin levels in dogs · gallbladder mucocele treatment in dogs
Abstract
BACKGROUND: Leptin has been shown to have various physiological and pathological roles in the canine gallbladder. In this study, we performed pre- and postoperative short-term follow-up analyses to confirm changes in serum leptin levels before and after cholecystectomy due to gallbladder mucocele (GBM) or cholelithiasis in dogs. RESULTS: Twenty-six cholecystectomized dogs (GBM: n = 14; cholelithiasis: n = 12) for prophylactic or clinical symptom relief were enrolled in the present study. Dogs were subgrouped according to clinical symptoms and prognosis after surgery as follows: 1) asymptomatic group (n = 13), 2) recovery group (n = 8), and 3) death group (n = 5). Liver enzymes, total bilirubin, lipid profiles, and leptin concentrations were determined from sera on the pre-operative day and at 1, 3, and 7 days postoperation. Serum leptin concentrations were gradually but significantly decreased in the asymptomatic group (p = 0.008, 0.004, and 0.004 on days 1, 3, and 7, respectively, compared with that before surgery) and the recovery group (p = 0.048 and 0.048 on days 3 and 7, respectively, compared with that before surgery). However, in the death group, leptin concentrations did not differ significantly over time (p = 0.564). Additionally, serum leptin levels in the recovery group (p = 0.006) and death group (p = 0.021) were significantly higher than those in the asymptomatic group. Liver enzymes and total bilirubin (T-Bil) were significantly decreased only in the recovery group, particularly on day 7. In the asymptomatic group, liver enzymes and T-Bil were not changed significantly over time, and in the death group, only T-Bil was significantly decreased on day 7. Total cholesterol and triglyceride levels were not significantly decreased over time in all groups. CONCLUSIONS: These results indicate that leptin is a potential biomarker reflecting the severity and prognosis of GBM and cholelithiasis both before and after cholecystectomy in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31238989/