Peer-reviewed veterinary case report
Kidney function changes in hyperthyroid cats after radioiodine
By Van Vertloo, Laura R et al.·Published in Journal of feline medicine and surgery·2023·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Changes in symmetric dimethylarginine and glomerular filtration rates in hyperthyroid cats undergoing radioiodine therapy.
- Species:
- cat
Plain-English summary
A group of 13 hyperthyroid cats underwent radioiodine therapy to treat their condition. Before treatment, the cats were tested for kidney function, and while their kidney filtration rate decreased after therapy, other kidney markers like creatinine and urea levels increased. Interestingly, the levels of symmetric dimethylarginine (SDMA), another kidney function marker, did not change significantly. This suggests that SDMA might not be the best indicator of kidney health in hyperthyroid cats after treatment.
People also search for: hyperthyroid cat treatment · cat kidney function tests · radioiodine therapy for cats
Abstract
OBJECTIVES: The aims of this study were to evaluate concentrations of symmetric dimethylarginine (SDMA) in hyperthyroid cats before and after radioiodine treatment, and to compare results with other variables used to assess kidney function in cats (creatinine, urine specific gravity [USG] and glomerular filtration rate [GFR] measured by renal scintigraphy). METHODS: Thirteen cats diagnosed with hyperthyroidism based on clinical signs and increased serum total thyroxine (TT4) were included in this prospective study. Study design included physical examination, complete blood count, serum chemistry, TT4, urinalysis and SDMA before treatment (T0) and at 1 month (T1) and 3 months post-treatment (T3). GFR was quantified by renal scintigraphy at T0 and T3. RESULTS: Median GFR decreased significantly from baseline (3.18 ml/kg/min; range 1.35-4.87) at T3 (2.22 ml/kg/min; range 1.81-3.42 [ = 0.005]). While median creatinine and serum urea nitrogen increased post-treatment (creatinine: T0 = 0.8 mg/dl [range 0.4-1.1], T1 = 1.3 mg/dl [range 0.9-2]; T3 = 1.65 mg/dl [range 0.8-2.8];<0.001; serum urea nitrogen: T0 = 23 mg/dl [range 15-26]; T1 = 27 mg/dl [range 20-40]; T3 = 27.5 mg/dl [range 20-36];<0.001), SDMA and USG did not change significantly (SDMA: T0 = 11 µg/dl [range 7-15]; T1 = 12 µg/dl [range 6-16]; T3 = 10.5 µg/dl [range 8-21]; = 0.789; USG: T0 = 1.030 [range 1.011-1.059]; T1 = 1.035 [range 1.012-1.044]; T3 = 1.030 [range 1.007-1.055]; = 0.792). CONCLUSIONS AND RELEVANCE: Our data suggest that factors other than GFR may affect serum SDMA in hyperthyroid cats and that SDMA does not offer an advantage over other biomarkers traditionally used to predict changes in renal function following radioiodine therapy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36892005/