Peer-reviewed veterinary case report
Nasal tumor size changes affect radiation dose in dogs
By Yoshikawa, Hiroto & Nolan, Michael W·Published in Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·2019·Department of Clinical Sciences·View original on PubMed →
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Original publication title: Changes in target volume during irradiation of canine intranasal tumors can significantly impact radiation dosimetry.
- Species:
- dog
Plain-English summary
A group of dogs with nasal tumors undergoing radiation therapy were studied to see how changes in tumor size affected treatment. Researchers found that as the tumors shrank, the amount of surrounding fluid also changed, which could impact the radiation dose delivered to the tumor and nearby healthy tissues. They discovered that when the tumor volume decreased significantly, it was important to adjust the radiation treatment plan to ensure the best outcome. This means that if a dog's nasal tumor shows signs of shrinking during treatment, the veterinarian may need to revise the radiation plan for optimal effectiveness.
People also search for: dog nasal tumor treatment · radiation therapy for dogs · changes in dog tumor size during treatment
Abstract
Nasal tumor size can change during radiation therapy (RT). The amount of peritumoral fluid (eg, mucohemorrhagic effusions) can also fluctuate. How often this occurs and the magnitude of change are unknown. Likewise, there are no data which describe dosimetric effects of these changing volumes during a course of RT in veterinary medicine. This study addresses that gap in knowledge. Using pet dogs with nasal tumors, three CT image sets were created. Different Hounsfield units were applied to the gross tumor volume (GTV) of each image set: unchanged, -1000 (AIR), -1000 (to the portion of the GTV that actually underwent volume reduction during clinical RT; REAL). Two plans were created: 18-fraction three-dimensional conformal RT (3DCRT) and three-fraction intensity-modulated stereotactic RT (IM-SRT). For nearby normal tissues and GTV, near-maximum doses (Dand D) and volumes receiving clinically significant doses were recorded. To verify "AIR" results, thermoluminescent dosimeters recorded dose in cadavers that were irradiated using both 3DCRT and IM-SRT plans. "AIR" scenario had ≤1.5 Gray (Gy) increases in Dand ≤3.2 cc increases of volume. "REAL" scenario had ≤0.97 Gy increases in Dand ≤0.55 cc increases of volume at clinically relevant doses. Both were statistical significant. Results suggest that near-complete resolution of GTV warrants plan revision.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31250950/