Peer-reviewed veterinary case report
Changes in saliva chemicals in dogs with hypothyroidism
By González-Arostegui, Luis Guillermo et al.·Published in Research in veterinary science·2022·Veterinary School, Spain·View original on PubMed →
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Original publication title: Changes in the salivary metabolome in canine hypothyroidism: A pilot study.
- Species:
- dog
Plain-English summary
A group of dogs with hypothyroidism, a condition where the body doesn't produce enough thyroid hormones, showed noticeable changes in their saliva compared to healthy dogs. Researchers found that 23 specific substances in the saliva were significantly lower in the hypothyroid dogs, which are linked to hormone production and metabolism. These findings suggest that saliva could potentially be used to help diagnose hypothyroidism in dogs. Understanding these changes may improve how veterinarians assess and treat this common endocrine disorder.
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Abstract
Hypothyroidism is the most commonly diagnosed endocrine disorder in dogs. It produces a deficiency of thyroid hormones which impacts negatively the dog's quality of life. The objective of this study is to evaluate the possible changes in the salivary metabolic profile in dogs with hypothyroidism. For this purpose, targeted metabolomics analysis performed by LC/MS analysis was made in saliva samples from a group of dogs with hypothyroidism and a group of healthy dogs. Twenty-three metabolites showed a significant decrease between hypothyroid and healthy dogs, most of these associated with thyroid hormone synthesis, catecholamine synthesis, and tyrosine and phenylalanine metabolism. Based on the results, it can be stated that hypothyroidism produces changes in the metabolome of saliva and some of them can reflect the metabolic changes presented in the disease and could serve as a potential biomarker of this condition.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36058168/