Peer-reviewed veterinary case report
Changes in saliva proteins linked to pyometra in female dogs
By Franco-Martínez, Lorena et al.·Published in Frontiers in veterinary science·2020·University of Murcia, Spain·View original on PubMed →
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Original publication title: Changes in the Salivary Proteome Associated With Canine Pyometra.
- Species:
- dog
Plain-English summary
A group of female dogs with pyometra, a serious infection of the uterus, had their saliva analyzed to look for changes in protein levels that could help diagnose the condition. Researchers found that certain proteins, including haptoglobin, were significantly higher in the saliva of dogs with pyometra compared to healthy dogs. These proteins are linked to inflammation and could serve as potential markers for the disease. While this study is a first step, it suggests that saliva tests might help vets diagnose pyometra more easily in the future.
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Abstract
The present study evaluated for the first time changes in the saliva proteome in bitches with pyometra through a high-throughput quantitative proteomic analysis. The aims were to explore whether saliva composition could reflect the physiopathological changes occurring in canine pyometra and to identify potential biomarkers of the disease. Saliva samples from six healthy (H) and six bitches with pyometra (P) were analyzed using tandem mass tags-based approach. Additionally, 15 samples were used for the validation of changes in haptoglobin (Hp) concentration in saliva of dogs with pyometra. Proteomic analysis quantified 707 proteins in saliva. Comparison of the two groups revealed 16 unique proteins significantly modulated in saliva, with S100A calcium-binding protein 12 (S100A12), vimentin, and Hp the most up-regulated in canine pyometra. According to PANTHER (Protein Analysis Through Evolutionary Relationships) classification tool, these proteins are mainly related to proinflammatory mediators, acute-phase proteins, and sepsis. In conclusion, it can be stated that there are changes in various proteins in saliva in canine pyometra reflecting different physiopathological changes occurring in this disease. These proteins could be a source of potential non-invasive biomarkers for this disease that should be confirmed in future studies.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32596263/