Peer-reviewed veterinary case report
Serum protein changes in dogs with pyometra infection
By Yoon, Ji-Seon et al.·Published in Frontiers in veterinary science·2021·College of Veterinary Medicine, South Korea·View original on PubMed →
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Original publication title: Changes in the Serum Protein Electrophoresis Profile in Dogs With Pyometra.
- Species:
- dog
Plain-English summary
A dog with pyometra, a serious infection of the uterus, showed changes in blood protein levels that indicate inflammation. The study found that dogs with this condition had lower levels of albumin and higher levels of certain proteins called globulins, along with increased levels of specific inflammatory markers like C-reactive protein (CRP) and serum amyloid A (SAA). These findings can help veterinarians monitor inflammation in dogs suffering from pyometra. Treatment typically involves surgery to remove the infected uterus, which can lead to recovery.
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Abstract
Serum proteins are involved in the regulation of inflammation, and therefore, serum protein profiling provides important insights in diverse inflammatory reactions. Accordingly, concentrations of single APPs, such as the C-reactive protein (CRP), serum amyloid A (SAA), and haptoglobin (Hp), have been described as indicators of inflammatory response in canine pyometra. However, there is little information regarding the overall serum protein profile obtained by SPE in canine pyometra. The present study was thus aimed to identify changes in the serum protein profile to monitor inflammation in dogs with pyometra using serum protein electrophoresis (SPE), in addition to the analysis of the concentration of single acute phase proteins (APPs). By SPE analysis, decreased levels of albumin and elevated levels of α2-globulin and β-globulin were noted in dogs with pyometra. In addition, the concentration of APPs, including the C-reactive protein (CRP), serum amyloid A (SAA), and haptoglobin (Hp), were also elevated in dogs with pyometra. The present study provides fundamental data for inflammatory indicators of canine pyometra.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33732740/