Peer-reviewed veterinary case report
How melatonin affects thyroid and metabolism hormones in male dogs
By Taheri, Pegah et al.·Published in BMC veterinary research·2019·Department of Clinical Sciences·View original on PubMed →
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Original publication title: Changes in thyroid hormones, leptin, ghrelin and, galanin following oral melatonin administration in intact and castrated dogs: a preliminary study.
- Species:
- dog
Plain-English summary
A group of healthy male mixed breed dogs were given melatonin to see how it affected their metabolism after being neutered (castrated). Over a month, researchers found that melatonin significantly lowered levels of certain thyroid hormones (T3 and T4) and other metabolic hormones like leptin and ghrelin in all the dogs. The decrease was more pronounced in the dogs that were not neutered compared to those that were. This suggests that melatonin might help balance metabolic hormones in dogs after castration.
People also search for: dog thyroid hormone treatment · melatonin for dogs · effects of neutering on dog metabolism
Abstract
BACKGROUND: Melatonin regulates metabolism and metabolism related hormones in mammalians. Castration has some adverse effects on the metabolic hormones of dog. This study was conducted to determine the effects of oral melatonin administration on metabolic hormones, as well as to compare changes of these hormones after administration of melatonin in castrated and intact dogs. Twenty healthy mixed breed mature male dogs were divided randomly into four groups (n = 5): melatonin (3 mg/10 kg(, castrated, castrated and melatonin treated, and negative control. Blood sample was collected from jugular vein weekly for 1 month. RESULTS: T3 and T4 hormones had a significant decrease within 1 month following administration of melatonin. No significant change was observed in concentration of FT3 and FT4 hormones. Leptin and ghrelin hormones also had a significant decrease in this period. Leptin and ghrelin had a more significant decrease in "non-castrated and melatonin treated" group compared to "castrated and melatonin treated" group. Galanin had a significant decrease but this neurotransmitter had no significant change in "non-castrated and melatonin treated" group in comparison to "castrated and melatonin treated" group. CONCLUSIONS: It seems that daily administration of melatonin capsule in all dogs can probably decrease concentration of T3 and T4 hormones and balance other metabolic hormones following castration. METHODS: The dogs underwent castration, melatonin treatment and blood sampling.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31088464/