Changes of microbiota level in urinary tract infections: A meta-analysis.

Abstract

No consensus has been reached on the dysbiosis signs of microbiota in patients with urinary tract infections (UTIs). This meta-analysis aimed to verify the relationship between microbiota levels and UTIs. PubMed, Web of Science, and Embase databases were retrieved for related articles published from inception until October 20, 2021. The standardized mean difference (SMD) and its related 95% confidence intervals (CIs) of the microbiota diversity and abundance were pooled under a random-effects model. Twelve studies were included in this meta-analysis. The pooled analysis revealed that the microbiota diversity was lower in patients with UTIs than in healthy individuals (SMD = -0.655, 95% CI = -1.290, -0.021, <i>I</i> ² = 81.0%, <i>P</i> = 0.043). The abundance of specific bacteria was higher in UTI subjects compared with healthy control individuals (SMD = 0.41, 95% CI = 0.07-0.74, <i>P</i> = 0.017), especially in North America patients with UTIs. Similar results were also found in studies with the total sample size being greater than 30. Importantly, <i>Escherichia coli</i> levels were increased in patients with UTI, whereas <i>Lactobacillus</i> levels decreased. <i>E. coli</i> and <i>Lactobacilli</i> have huge prospects as potential microbiota markers in the treatment of UTIs.