Peer-reviewed veterinary case report
Sphincter of Oddi movement changes in dogs after gallbladder removal
By Fan, Ming Ming et al.·Published in Journal of digestive diseases·2012·Department of General Surgery, China·View original on PubMed →
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Original publication title: Changes of the sphincter of Oddi motility in dog after cholecystectomy.
- Species:
- dog
Plain-English summary
A group of eight Beagle dogs underwent surgery to remove their gallbladders (cholecystectomy) to see how it affected a specific muscle controlling bile flow (the sphincter of Oddi). After the surgery, the pressure in the bile duct increased, but the overall movement patterns of the sphincter remained mostly the same, just with shorter cycles. However, the sphincter's ability to relax in response to a hormone that stimulates digestion (cholecystokinin) was less effective after the surgery. The dogs did not show significant changes in their overall motility, but the response to certain stimuli was altered.
People also search for: Beagle dog gallbladder surgery effects · sphincter of Oddi function in dogs · cholecystectomy recovery in dogs
Abstract
OBJECTIVE: To determine the effect of cholecystectomy on the motility of the sphincter of Oddi (SO). METHODS: Pressures of common bile duct (CBD), SO motility and its response to bolus injections of cholecystokinin (CCK, 20 ng/kg and 100 ng/kg) were detected respectively by manometry in eight Beagle dogs before and after cholecystectomy. RESULTS: After cholecystectomy the CBD pressure increased 2.18 ± 1.86 mmHg, while the cyclical motion pattern of SO still existed but with a shortened cycle duration. The basal pressure (BP), phasic contraction amplitude (PCA), phasic contraction frequency (PCF) and its mode of propagation did not change significantly. Under the stimulation of CCK after cholecystectomy, although the motion patterns of SO were similar to those before cholecystectomy, the greatest inhibitory efficacy of BP and PCA all decreased with the prolonged excitement duration and the increased percentage of retrograde contraction. CONCLUSIONS: Shortly after a cholecystectomy in Beagle dogs, the CBD pressure increased, SO motilities did not change significantly during the interdigestive phase except with a shortened cycle duration. Its relaxation responded to CCK was weakened with a confused contraction pattern.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22188915/