Peer-reviewed veterinary case report
Canine mast cell tumor cells tested for virus treatment sensitivity
By Mehrani, Yeganeh et al.·Published in Veterinary and comparative oncology·2025·Department of Pathobiology, Canada·View original on PubMed →
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Original publication title: Characterisation and Sensitivity of a Canine Mast Cell Tumour Line to Oncolytic Viruses.
- Species:
- dog
Plain-English summary
A study looked at a type of skin cancer called mast cell tumors (MCTs) in dogs, which are quite common. Researchers tested several viruses to see if they could effectively kill the cancer cells from these tumors. One particular virus, called rVSV-Δm51, showed the best results in the lab. While this is promising for future treatments, more research is needed to see if these viruses can help dogs with MCTs in real-life situations.
People also search for: dog mast cell tumor treatment · canine skin cancer options · oncolytic virus therapy for dogs
Abstract
Canine mast cell tumours (MCTs) are one of the most common skin cancers of dogs. Surgical removal is the primary treatment, but recurrence and metastasis can occur even with low-grade tumours. As a result, new treatment strategies are being sought. We tested the potential of several oncolytic viruses (OVs) to infect and kill a cell line isolated from a canine MCT. Employing a resazurin-based metabolic assay and flow cytometry technology, we used recombinant vesicular stomatitis virus (rVSV-Δm51), avian orthoavulavirus-1 (AOaV-1), and Orf viruses in our assessment. Our study aimed to evaluate the potential of oncolytic virotherapy in treating canine cancers. We found that MCT-1 cells showed different sensitivities to the OVs, with rVSV-Δm51 showing the most promising results in vitro. These findings suggest that further investigation into using OVs for treating canine MCTs is needed, although clinical efficacy is yet to be determined.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39526468/