Peer-reviewed veterinary case report
Blood clotting changes in dogs with thrombosis explained
By Bauer, N & Moritz, A·Published in The Journal of small animal practice·2013·Department of Veterinary Clinical Sciences, Germany·View original on PubMed →
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Original publication title: Characterisation of changes in the haemostasis system in dogs with thrombosis.
- Species:
- dog
Plain-English summary
A group of dogs diagnosed with thrombosis (a condition where blood clots form inappropriately) showed varying states of blood clotting ability. Some dogs had normal clotting, while others were found to be in a hypercoagulable state, meaning their blood was more prone to clotting. Tests revealed that these dogs had lower levels of certain proteins that help regulate clotting, which could lead to complications. Understanding these changes can help veterinarians better manage dogs with thrombosis and prevent future clotting issues.
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Abstract
OBJECTIVE: To prospectively assess (2008 to 2009) all phases of coagulation including thromboelastography in dogs with thrombosis to determine if thrombosis is associated with hypercoagulable states. METHODS: Coagulation reaction in dogs with thrombosis (n = 7) diagnosed by diagnostic imaging or histopathology was compared with 56 control dogs. Dogs pretreated with antiplatelet and anticoagulation drugs were excluded. Thromboelastographic G-values >10 · 3 Kdyn/cm(2) were used to define a hypercoagulable state. RESULTS: Compared with the controls, there was a significantly higher mean platelet component indicating lower platelet activation status (17 · 99 ±1 · 36 versus 20 · 48 ±2 · 04 g/dL, P = 0 · 0004), increased thromboelastographic G-value (6 · 4 ±1 · 6 versus 13 · 1 ±6 · 2 Kdyn/cm(2) , P = 0 · 0029), activated partial thromboplastin time, fibrinogen, D-dimers (all: P < 0 · 0001) as well as decreased antithrombin (P = 0 · 0049), factor VIII (P < 0 · 0001), protein C (P < 0 · 0001), protein S (P = 0 · 0373) and activated protein C-ratio (P = 0 · 0013). On the basis of thromboelastographic G-value, three of six thromboelastographic tracings were classified as normocoagulable and three as hypercoagulable. CLINICAL RELEVANCE: In dogs with thrombosis, both normo- and hypercoagulable states are present and activated protein C resistance is common.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23458642/