Peer-reviewed veterinary case report
How corneal cell changes help diagnose dry eye in dogs
By Lejarza-Ilaro, Mikel et al.·Published in The Veterinary record·2019·Lejarza Veterinay Center, Spain·View original on PubMed →
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Original publication title: Characterisation of corneal impression cytology in dogs and its application in the diagnosis of keratoconjunctivitis sicca.
- Species:
- dog
Plain-English summary
A group of dogs with eye problems, specifically keratoconjunctivitis sicca (KCS), were examined using a technique called impression cytology to collect samples from their corneas. The study found that dogs with lower tear production had more noticeable changes in their corneal cells, which can help veterinarians diagnose KCS more effectively, especially in its early stages. This method could be a valuable tool for vets when assessing eye health in dogs.
People also search for: dog eye problems · keratoconjunctivitis sicca treatment · dog tear production issues
Abstract
OBJECTIVE: Determine morphological and morphometric parameters of corneal epithelium in dogs, and determine the cellular alterations that occur in canine keratoconjunctivitis sicca (KCS) using impression cytology. STUDY ANIMALS: 60 dogs divided into two groups: dogs with Schirmer tear test (STT) at least 15 mm/minute and absence of ocular disease, and dogs with STT less than 15 mm/minute and clinical signs of KCS. PROCEDURES: Impression cytology was used to collect corneal samples. The percentage of eyes with cell changes, the number of such cells and the percentage of cells with structural alterations in each group were determined. The possible correlation between corneal epithelium alterations and decreased tear production was evaluated. RESULTS: A significant positive correlation existed between STT and the area of the cytoplasm and nucleus of corneal cells. A significant negative correlation was found between STT ​​and the nucleus/cytoplasm ratio, and the presence of cellular changes. A significant difference existed between the numbers of pyknotic nuclei, being higher among animals with all stages of KCS. CONCLUSION: Corneal impression cytology can be used to assess the corneal epithelium in healthy eyes and eyes with KCS, demonstrating its usefulness as a diagnostic tool especially in mild and early cases.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31019006/