Peer-reviewed veterinary case report
Airway inflammation from cadmium inhalation in healthy dogs
By Bolognin, M et al.Ā·Published in Veterinary journal (London, England : 1997)Ā·2009Ā·Department for Clinical SciencesĀ·View original on PubMed ā
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Original publication title: Characterisation of the acute and reversible airway inflammation induced by cadmium chloride inhalation in healthy dogs and evaluation of the effects of salbutamol and prednisolone.
- Species:
- dog
Plain-English summary
A group of healthy dogs experienced temporary breathing problems after inhaling cadmium chloride, which caused inflammation in their airways. The dogs showed symptoms like increased coughing and difficulty breathing, and tests revealed a rise in certain inflammatory cells in their blood and lungs. When treated with prednisolone, a steroid, there was a slight reduction in inflammation, but it didn't significantly improve their breathing or airway sensitivity. Salbutamol, a common asthma medication, did not help either. Overall, the inflammation was reversible, and the dogs recovered without lasting effects.
People also search for: dog breathing problems after inhalation Ā· prednisolone for dog bronchitis Ā· salbutamol effectiveness in dogs
Abstract
The aims of this study were firstly to characterise a model of subclinical and reversible bronchial inflammation induced by cadmium chloride inhalation in healthy dogs and then to examine the effect of prednisolone or salbutamol treatment on the resulting bronchitis. The model characterisation and the effects of treatment were studied using clinical symptoms, haematology, thoracic radiography, bronchoscopy and bronchoalveolar lavage, barometric whole-body plethysmography and histamine broncho-provocation tests. In addition, the activity of matrix metalloproteinases (MMP)-2 and -9 were determined in serum and bronchoalveolar lavage fluid (BALF). Cadmium inhalation induced: (1) a transient bronchial inflammation, dominated by neutrophils; (2) a neutrophilia of the blood that persisted for up to 4 weeks; (3) a transient increased bronchial reactivity, and (4) a significant increase in MMP-9 activity in the BALF. Prednisolone treatment reduced the influx of inflammatory cells into the BALF, but not significantly, had no effect on pulmonary function, and did not reduce of airway hypersensitivity. Salbutamol had almost no effect on any of the parameters investigated.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18037312/