Peer-reviewed veterinary case report
Characterization and biological evaluation of six new dimeric lignans with an unusual α,β-unsaturated ketone motif from Zanthoxylum simulans.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2014
- Authors:
- Wang, Jun-Feng et al.
- Affiliation:
- CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology South China Sea Institute of Oceanology · China
- Species:
- rodent
Abstract
Investigation of the bark of Zanthoxylum simulans afforded six new dimeric lignans zanthpodocarpins C-H (1-6) bearing an unusual α,β-unsaturated ketone group. The new structures of 1-6 were determined by using detailed spectroscopic analysis. All of the isolated compounds were examined for their inhibitory effects against rat joint synovial cell and splenocyte proliferation. Compounds 1-6 showed potent anti-inflammatory activities with IC50 values ranging from 18.6 to 36.1μM, and 13.8 to 74.3μM.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25205192/