Peer-reviewed veterinary case report
Stem cell treatment improves elbow arthritis in dogs over 1 year
By Kriston-Pál, Éva et al.·Published in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire·2017·Institute of Genetics, United Kingdom·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Characterization and therapeutic application of canine adipose mesenchymal stem cells to treat elbow osteoarthritis.
- Species:
- dog
Plain-English summary
A group of 30 dogs with elbow osteoarthritis, including those with elbow dysplasia, received injections of stem cells taken from fat tissue to help improve their condition. The treatment was done without any additional medications, and over the course of a year, the dogs showed significant improvement in their lameness. In one case, a follow-up procedure revealed that the cartilage in the joint had regenerated, which was confirmed by a biopsy showing healthy cartilage. This suggests that using stem cells from fat tissue could be a promising and effective way to treat elbow joint issues in dogs.
People also search for: dog elbow arthritis treatment · stem cell therapy for dogs · dog lameness improvement · elbow dysplasia in dogs · canine osteoarthritis treatment options
Abstract
Visceral adipose tissue (AT) obtained from surgical waste during routine ovariectomies was used as a source for isolating canine mesenchymal stem cells (MSCs). As determined by cytofluorimetry, passage 2 cells expressed MSC markers CD44 and CD90 and were negative for lineage-specific markers CD34 and CD45. The cells differentiated toward osteogenic, adipogenic, and chondrogenic directions. With therapeutic aims, 30 dogs (39 joints) suffering from elbow dysplasia (ED) and osteoarthritis (OA) were intra-articularly transplanted with allogeneic MSCs suspended in 0.5% hyaluronic acid (HA). A highly significant improvement was achieved without any medication as demonstrated by the degree of lameness during the follow-up period of 1 y. Control arthroscopy of 1 transplanted dog indicated that the cartilage had regenerated. Histological analysis of the cartilage biopsy confirmed that the regenerated cartilage was of hyaline type. These results demonstrate that transplantation of allogeneic adipose tissue-derived mesenchymal stem cells (AT-MSCs) is a novel, noninvasive, and highly effective therapeutic tool in treating canine elbow dysplasia.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28197017/