Peer-reviewed veterinary case report
How chloroquine causes itching in dogs and tested treatments
By Aberg, Gunnar A K et al.·Published in Drug development research·2015·Bridge Pharma Inc., United States·View original on PubMed →
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Original publication title: Characterization and Validation of a Canine Pruritic Model.
- Species:
- dog
Plain-English summary
A group of beagle dogs experienced itching after receiving an injection of chloroquine, a medication known to cause itching in humans. Researchers created this model to better understand and test treatments for itching in dogs. They found that both oclacitinib and prednisolone, as well as a new compound called norketotifen, effectively reduced the itching caused by chloroquine. The study showed that norketotifen worked well, with higher doses leading to less scratching. This research could help develop better treatments for dogs suffering from itching.
People also search for: dog itching treatment · beagle scratching · norketotifen for dogs · oclacitinib for dog itching · prednisolone for dog allergies
Abstract
Preclinical Research The mechanisms mediating canine pruritus are poorly understood with few models due to limited methods for inducing pruritus in dogs. Chloroquine (CQ) is a widely used antimalarial drug that causes pruritus in humans and mice. We have developed a canine model of pruritus where CQ reliably induced pruritus in all dogs tested following intravenous administration. This model is presently being used to test antipruritic activity of drug candidate molecules. This publication has been validated in a blinded cross-over study in eight beagle dogs using the reference standards, oclacitinib and prednisolone, and has been used to test a new compound, norketotifen. All compounds reduced CQ-induced pruritus in the dog. The sensitivity of the model was demonstrated using norketotifen, which at three dose levels, dose-dependently, inhibited scratching events compared with placebo.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26220424/