Peer-reviewed veterinary case report
New implant tested to widen prostate urethra in male dogs
By Chughtai, Bilal et al.·Published in Urology·2022·New York Presbyterian Hospital-Weill Cornell, United States·View original on PubMed →
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Original publication title: Characterization of a Novel Implant Intended to Expand and Reshape the Prostatic Urethra for the Treatment of Benign Prostatic Hyperplasia: A Pre-Clinical Feasibility Study in the Canine Model.
- Species:
- dog
Plain-English summary
Eight adult male dogs with urinary issues due to an enlarged prostate were treated with a new device designed to widen the urethra. After the device was placed, it successfully increased the urethral width without causing any major complications, and all dogs remained continent, meaning they did not have any issues with urination. Some minor side effects included slight bleeding and temporary blood in the urine, but overall, the device showed a good safety profile and did not lead to any serious problems like stones or infections. This suggests that the device could be a promising option for treating similar urinary issues in dogs.
People also search for: dog enlarged prostate treatment · urinary problems in male dogs · prostate surgery for dogs
Abstract
OBJECTIVE: To evaluate the safety, feasibility, and tissue response of a novel device for the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia, using the first-generation Urocross Expander System (Mercury Expander System). METHODS: The implant was deployed and retrieved using flexible cystoscope in 8 adult male canines, separated into three study arms by retrieval date (1-, 6-, and 12- months post-deployment). Cystoscopy and urethrograms verified implant position/diameter; bladder neck and external sphincter function/changes; prostatic tissue response; and implant condition. One-month post-retrieval, the prostate and surrounding tissue was sectioned and evaluated by a veterinary pathologist. RESULTS: All implants were successfully deployed in the prostatic urethra. Urethral width was increased (6.9 ± 1.8 mm to 10.2 ± 0.6 mm, P = .012) and preserved through the dwell period. Urethral length and sphincter diameters didn't significantly change. All subjects (n = 8) remained continent without obstruction or retention. Adverse events included incisional site bleeding (n = 2) and transient hematuria (n = 3). One implant migrated into the bladder and spontaneously repositioned into the prostatic urethra. Post-retrieval, explant surfaces demonstrated no tissue growth, encrustation or stone formation. Imaging revealed contact site erythema and indentation, but no stones, strictures, perforations, erosions, nor ulcerations. Histopathology revealed glandular acinar changes, inflammation, and fibrosis. CONCLUSION: The first generation of the Urocross Expander System demonstrated a favorable safety profile in the canine model. Changes in the prostatic urethra shape were noted with an increase in urethral width during the dwell period with minimal tissue changes. Further, the implant didn't demonstrate any encrustation, tissue growth or stone formation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34728332/