Peer-reviewed veterinary case report
New highly contagious canine distemper virus strain
By Qiao, J et al.·Published in Acta virologica·2011·Department of Veterinary Medicine, China·View original on PubMed →
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Original publication title: Characterization of a new dog isolate of canine distemper virus from China.
- Species:
- dog
Plain-English summary
A vaccinated dog in China died from a severe infection caused by a new strain of canine distemper virus (CDV) called XJ2. This strain was found to be highly contagious and virulent, meaning it can cause serious illness even in vaccinated dogs. Researchers studied the genetic makeup of this virus to understand its characteristics better. Unfortunately, dogs that were not previously exposed to CDV and were given the XJ2 strain developed severe symptoms and did not survive. This highlights the importance of ongoing vaccination and monitoring for new strains of the virus.
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Abstract
Canine distemper virus (CDV) is a highly contagious pathogen of dogs. Vaccination is an effective way to protect dogs from CDV infection, but occasionally fails. In the present study, a wild type (wt) CDV, named XJ2, was isolated from a dead vaccinated dog. The hemagglutinin (H) gene of the XJ2 was amplified and analyzed for the molecular characteristics including N-glycosylation sites, phylogenesis, hydrophobicity and epitopes. The data indicated that XJ2 was a genetic variant strain of CDV. CDV-sero-negative dogs were inoculated intranasally with XJ2, developed severe clinical symptoms and died, suggesting high virulence.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22149495/