Peer-reviewed veterinary case report
Characterization of a new dog isolate of canine distemper virus from China.
- Journal:
- Acta virologica
- Year:
- 2011
- Authors:
- Qiao, J et al.
- Affiliation:
- Department of Veterinary Medicine · China
- Species:
- dog
Abstract
Canine distemper virus (CDV) is a highly contagious pathogen of dogs. Vaccination is an effective way to protect dogs from CDV infection, but occasionally fails. In the present study, a wild type (wt) CDV, named XJ2, was isolated from a dead vaccinated dog. The hemagglutinin (H) gene of the XJ2 was amplified and analyzed for the molecular characteristics including N-glycosylation sites, phylogenesis, hydrophobicity and epitopes. The data indicated that XJ2 was a genetic variant strain of CDV. CDV-sero-negative dogs were inoculated intranasally with XJ2, developed severe clinical symptoms and died, suggesting high virulence.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22149495/