Peer-reviewed veterinary case report
Characterization of amyloid in equine recurrent uveitis as AA amyloid.
- Journal:
- Journal of comparative pathology
- Year:
- 2014
- Authors:
- Ostevik, L et al.
- Affiliation:
- Faculty of Veterinary Medicine and Biosciences
- Species:
- horse
Plain-English summary
Two horses with a long-term eye condition called equine recurrent uveitis (ERU) were studied. They had signs of inflammation in their eyes, and tests showed abnormal protein deposits known as amyloid in the eye tissues. One horse had a detailed examination that confirmed these amyloid deposits were made up of a specific type called AA amyloid, which is linked to inflammation. The results indicate that this type of amyloid buildup can happen in the eyes of horses suffering from ERU.
Abstract
Two horses with chronic uveitis and histological lesions consistent with equine recurrent uveitis (ERU) were examined. Microscopical findings in the ciliary body included deposits of amyloid lining the non-pigmented epithelium, intracytoplasmic, rod-shaped, eosinophilic inclusions and intraepithelial infiltration of T lymphocytes. Ultrastructural examination of the ciliary body of one horse confirmed the presence of abundant extracellular deposits of non-branching fibrils (9-11 nm in diameter) consistent with amyloid. Immunohistochemistry revealed strong positive labelling for AA amyloid and mass spectrometry showed the amyloid to consist primarily of serum amyloid A1 in both cases. The findings suggest that localized, intraocular AA amyloidosis may occur in horses with ERU.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24975895/