Peer-reviewed veterinary case report
H3N2 canine flu virus found in Tibetan mastiffs in China
By Teng, Qiaoyang et al.·Published in Veterinary microbiology·2013·Shanghai Veterinary Research Institute, China·View original on PubMed →
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Original publication title: Characterization of an H3N2 canine influenza virus isolated from Tibetan mastiffs in China.
- Species:
- dog
Plain-English summary
Ten 3-month-old Tibetan mastiffs became sick with severe respiratory issues just two days after being purchased from an exhibition, and unfortunately, four of them died two weeks later. A canine influenza virus (H3N2) was found in the lungs of one of the deceased dogs, which was closely related to similar viruses found in South Korea. This virus was able to infect other dogs, causing serious breathing problems. The findings suggest that dogs could play a role in spreading avian influenza viruses.
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Abstract
Ten 3-month-old Tibetan mastiffs became ill 2 days after they were bought from a Tibetan mastiff exhibition, and 4 of them died 2 weeks later. A canine influenza virus (ZJ0110) was isolated from the lung of a deceased Tibetan mastiff and was characterized in detail. Sequence analysis indicated that the 8 genes of the canine isolate were most similar to those of avian-origin canine influenza viruses (H3N2) isolated in South Korea in 2007, with which they shared >98% sequence identity. ZJ0110 could experimentally infect 6-month-old beagles by intranasal inoculation and by airborne transmission, causing severe respiratory syndrome. Moreover, ZJ0110 could replicate in the upper respiratory tracts of mice and guinea pigs, and the virus titer was comparable to that in the upper respiratory tracts of dogs. Although the virus was genetically of avian origin, ZJ0110 could not experimentally infect chicken or ducks by intranasal inoculation. These results suggest that dogs might be an intermediary host in which avian influenza viruses adapt to replicate in mammals.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23107656/