Peer-reviewed veterinary case report
Boxer dog with widespread tumors diagnosed as mast cell cancer
By Zemke, D et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2001·Department of Microbiology and Molecular Genetics, United States·View original on PubMed →
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Original publication title: Characterization of an undifferentiated malignancy as a mast cell tumor using mutation analysis in the proto-oncogene c-KIT.
- Species:
- dog
Plain-English summary
A 6.5-year-old female Boxer was put to sleep after her health quickly worsened and she developed multiple tumor masses. The largest tumor was in the same spot as a mast cell tumor that had been previously removed. During the examination, doctors found many nodules throughout her body, including in her lymph nodes. Tests showed that the tumors were linked to the earlier mast cell tumor, confirming they were all mast cell tumors. This case highlights how advanced testing can help identify the exact type of cancer in pets.
People also search for: Boxer dog tumors · mast cell tumor treatment · why is my dog developing lumps · dog cancer diagnosis · symptoms of mast cell tumors in dogs
Abstract
A 6.5-year-old female Boxer was euthanized and presented for necropsy following rapid clinical decline concomitant with the development of numerous tumor masses. The largest of these masses was in the same location as a mast cell tumor that had been previously removed from this dog. Gross examination revealed the presence of nodules 5-200 mm in diameter throughout the body, including the lymph nodes. Histologic analysis showed an influx of round cells with no granules, leading to the provisional diagnosis of systemic lymphosarcoma. Immunohistochemical staining for B- and T-lymphocyte antigens was negative. Molecular tests were used to identify a tandem duplication in the c-KIT proto-oncogene from both the earlier mast cell tumor and the current nodules, implicating a common origin. Addition of molecular testing to conventional necropsy evaluations allowed a definitive diagnosis of mast cell tumors.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11478608/