Peer-reviewed veterinary case report
Oral warts outbreak in Korean dogs studied by genetic tests
By Yhee, Ji-Young et al.·Published in Journal of veterinary science·2010·Department of Veterinary Pathobiology, South Korea·View original on PubMed →
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Original publication title: Characterization of canine oral papillomavirus by histopathological and genetic analysis in Korea.
- Species:
- dog
Plain-English summary
A group of 40 dogs at a breeding farm in Korea developed oral warts, which are caused by canine oral papillomavirus (COPV). This condition is common in dogs and can lead to growths in the mouth that may cause discomfort or difficulty eating. The researchers conducted tests to confirm the presence of the virus and analyzed its genetic makeup. While the study focused on understanding the virus better, it highlights the importance of monitoring oral health in dogs, especially in breeding environments.
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Abstract
In August 2008, forty dogs out of 400 developed oral warts in a breeding farm in Korea. Canine oral papilloma infection is a common disease in dogs. However, there has been no report of an outbreak of canine oral papillomavirus (COPV) in a group of dogs or in dog breeding farms in Korea, and the genetic analysis of COPV in Korea has yet to be performed. This study diagnosed canine oral papilloma from the oral samples of these dogs based on histopathological examination and immunohistochemistry. Polymerase chain reaction was applied to amplify the corresponding products using preexisting primer sets for COPV and a universal human papillomavirus targeting L1 gene. Further genetic analysis of the major viral capsid gene L1 confirms the sequences of Korean COPV, which shows a close relationship to previously reported COPV. This study describes the histopathological and immunohistochemical characteristics of canine oral papilloma in a group of breeding dogs in Korea and discloses the complete L1 gene sequences of Korean COPV.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20195061/