Peer-reviewed veterinary case report
Hyaline bodies found in liver cancer of 13-year-old Yorkshire dog
By Masserdotti, Carlo et al.·Published in Research in veterinary science·2014·Veterinary Diagnostic Laboratory "San Marco", Italy·View original on PubMed →
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Original publication title: Characterization of cytoplasmic hyaline bodies in a hepatocellular carcinoma of a dog.
- Species:
- dog
Plain-English summary
A 13-year-old Yorkshire dog was brought to the vet for symptoms like not wanting to eat, being unusually tired, and drinking more water than normal. After examining a large mass in the dog's abdomen, the vet performed fine-needle aspirates and biopsies, which confirmed the presence of liver cancer (hepatocellular carcinoma) with unusual protein deposits in the liver cells. Unfortunately, the report does not mention the treatment or outcome for this dog.
People also search for: dog liver cancer symptoms · Yorkshire dog not eating · treatment for dog hepatocellular carcinoma
Abstract
This report describes the morphological and immunohistochemical features of intracytoplasmic inclusion bodies found in a 13-year-old Yorkshire dog with a hepatocellular carcinoma and referred for anorexia, lethargy and mild polydipsia. Fine-needle aspirates of the large abdominal mass revealed high number of pleomorphic neoplastic hepatocytes, containing round to polygonal, well-demarcated, hyaline bodies. Same findings were histologically confirmed on multiple biopsies. Immunohistochemically, the inclusion bodies were negative for alpha-1-antitrypsin, carcinoembryonary antigen, fibrinogen, IgG, IgM, cytokeratins 7, 8, 18, 19, 20. By transmission electron microscopy, the cytoplasmic inclusions were composed of granular homogeneous or reticulated electrondense matrix, enclosed within dilated rough endoplasmic reticulum or remnants of its membranes, consistent with proteinaceous material accumulated within neoplastic hepatocytes due to aberrant protein secretion or transport. This is the first detailed characterization of hyaline cytoplasmic inclusion bodies in canine hepatocellular carcinoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24374119/