Peer-reviewed veterinary case report
Characterization of Guinea Pig Mitogenic Factor
- Journal:
- The Journal of Immunology
- Year:
- 1975
- Authors:
- Mills, John A
- Affiliation:
- Massachusetts General Hospital, Harvard Medical School , Boston, Massachusetts 02114 · United States
- Species:
- rodent
Abstract
Abstract Guinea pig mitogenic factor (M.F.) was identified in antigen-stimulated guinea pig lymph node lymphocyte cultures by the ability of supernatants to stimulate DNA synthesis in non-immune lymphocytes. Its activity is not augmented by the presence of antigen and it will stimulate lymphocytes made unresponsive to the eliciting antigen. M.F. production by lymphocytes is detectable within 6 hr after antigen stimulation and reaches a maximum at 24 hr. DNA synthesis produced by M.F. is maximal at 48 hr. M.F. is heat stable at 60°C. Its molecular weight is in the range of 20,000 to 30,000 daltons. M.F. activity appears to be relatively resistant to the action of proteolytic enzymes.
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Search related cases →Original publication: https://doi.org/10.4049/jimmunol.114.1_part_1.45