Peer-reviewed veterinary case report
Drug-resistant Staphylococcus pseudintermedius in Australian dogs
By Siak, Meng et al.·Published in Journal of medical microbiology·2014·Animal Dermatology Clinic - Perth, Australia·View original on PubMed →
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Original publication title: Characterization of meticillin-resistant and meticillin-susceptible isolates of Staphylococcus pseudintermedius from cases of canine pyoderma in Australia.
- Species:
- dog
Plain-English summary
A group of dogs with skin infections called pyoderma were found to have a type of bacteria known as meticillin-resistant Staphylococcus pseudintermedius (MRSP). This bacteria is resistant to many common antibiotics, making it harder to treat. In a study of 19 dogs, 12 were identified with MRSP, which showed resistance to multiple antibiotics, including gentamicin and erythromycin. This is concerning because it highlights the need for new treatment options for dogs suffering from recurrent skin infections.
People also search for: dog skin infection treatment · MRSP in dogs · antibiotic-resistant dog infections · pyoderma in dogs · dog skin problems antibiotics
Abstract
Meticillin-resistant Staphylococcus pseudintermedius (MRSP) has recently emerged as a worldwide cause of canine pyoderma. In this study, we characterized 22 S. pseudintermedius isolates cultured from 19 dogs with pyoderma that attended a veterinary dermatology referral clinic in Australia in 2011 and 2012. Twelve isolates were identified as MRSP by mecA real-time PCR and phenotypic resistance to oxacillin. In addition to β-lactam resistance, MRSP isolates were resistant to erythromycin (91.6 %), gentamicin (83.3 %), ciprofloxacin (83.3 %), chloramphenicol (75 %), clindamycin (66 %), oxytetracycline (66 %) and tetracycline (50 %), as shown by disc-diffusion susceptibility testing. Meticillin-susceptible S. pseudintermedius isolates only showed resistance to penicillin/ampicillin (90 %) and tetracycline (10 %). PFGE using the SmaI restriction enzyme was unable to type nine of the 12 MRSP isolates. However the nine isolates provided the same PFGE pulsotype using the Cfr91 restriction enzyme. Application of the mec-associated direct repeat unit (dru) typing method identified the nine SmaI PFGE-untypable isolates as dt11cb, a dru type that has only previously been associated with MRSP sequence type (ST)45 isolates that possess a unique SCCmec element. The dt11cb isolates shared a similar multidrug-resistant antibiogram phenotype profile, whereas the other MRSP isolates, dt11a, dt11af (dt11a-associated) and dt10h, were resistant to fewer antibiotic classes and had distinct PFGE profiles. This is the first report of MRSP causing pyoderma in dogs from Australia. The rapid intercontinental emergence and spread of multidrug-resistant MRSP strains confirms the urgent need for new treatment modalities for recurrent canine pyoderma in veterinary practice.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24994658/