Peer-reviewed veterinary case report
Characterization of microminipig as a laboratory animal for pharmacological study by analyzing bepridil-induced cardiovascular responses.
- Journal:
- Journal of pharmacological sciences
- Year:
- 2020
- Authors:
- Nunoi, Yoshio et al.
- Affiliation:
- Department of Pharmacology · Japan
- Species:
- dog
Abstract
Since microminipig is becoming attractive model for various cardiac electropharmacological applications, which may meet consideration of 3Rs. We characterized microminipigs by analyzing how multi-ionic channel inhibitor bepridil may affect their in situ hearts in comparison with dogs. Bepridil in doses of 0.3 and 3.0 mg/kg were intravenously administered over 10 min under halothane anesthesia (n = 4). Microminipigs may be less sensitive for Iinhibition of bepridil, whereas they are more responsive to I, Iand Isuppression than dogs. This information would help predict cardiovascular effects of a drug in patients with the remodeled hearts having similar electrophysiological profile to microminipigs.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32144028/